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Metabolic acidosis is a condition in which there is too much acid in the body fluids.
Acidosis - metabolic
Causes, incidence, and risk factors
Metabolic acidosis occurs when the body produces too much acid, or when the kidneys are not removing enough acid from the body.
There are several types of metabolic acidosis:
- Diabetic acidosis (also called diabetic ketoacidosis and DKA) develops when substances known as ketone bodies, which are acidic, build up during uncontrolled type 1 diabetes
- Hyperchloremic acidosis results from excessive loss of sodium bicarbonate from the body, as can happen with severe diarrhea
- Lactic acidosis is a buildup of lactic acid. It can be caused by:
- Exercising for a very long time
- Liver failure
- Low blood sugar (hypoglycemia)
- Medications such as salicylates
- Prolonged lack of oxygen from , , or severe
Other causes of metabolic acidosis include:
- Kidney disease (distal tubular acidosis and proximal renal tubular acidosis)
- Poisoning by aspirin, ethylene glycol (found in antifreeze), or methanol
- Severe dehydration
Most symptoms are caused by the underlying disease or condition that is causing the metabolic acidosis. Metabolic acidosis itself usually causes rapid breathing. Confusion or lethargy may also occur. Severe metabolic acidosis can lead to shock or death. In some situations, metabolic acidosis can be a mild, chronic (ongoing) condition.
Signs and tests
- Arterial blood gas
- Serum electrolytes
- Urine pH
Arterial blood gas analysis or a serum electrolytes test (such as a basic metabolic panel) will confirm acidosis is present and determine whether it is respiratory acidosis or metabolic acidosis.
Other test may be needed to determine the cause of the acidosis.
Treatment is aimed at the underlying condition. In certain circumstances, sodium bicarbonate (baking soda) may be given to improve the acidity of the blood.
What can be expected will depend on the underlying disease causing the metabolic acidosis.
When very severe, metabolic acidosis can lead to shock or death.
Calling your health care provider
Seek medical treatment if you develop symptoms of any disease that can cause metabolic acidosis.
Keeping type 1 diabetes under control may help prevent diabetic ketoacidosis, one type of metabolic acidosis.
Seifter JL. Acid-base disorders.In: Goldman L, Schafer AI, eds.Cecil Medicine. 24th ed.Philadelphia,PA: Saunders Elsevier; 2011:chap 120.
- Last reviewed on 11/17/2011
- David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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